I'm sure the designers of ships in the TU have to consider thrust lines and getting them lined up so they go through a ship's centre of mass, and that they need to make sure that cargo holds are placed such that cargos within the ship's designed mass limits won't move the CoM too much. I'm also sure that proper, balanced placement of high-mass cargo is part of the cargomaster's job, along with making sure that cargo is placed so that the first stuff to come out isn't buried in the back corners, that any cargo passengers are entitled to access in-flight is actually accessible, and so on.