I've just begun a solo game centred around the misadventures of the 4-strong crew of a far trader, based on MGT rules and also using Mythic to generate plot elements.
When used as a "GM emulator", Mythic is scene-based. You come up with the scene setup then roll to check if it's altered, and if so, how. There are 3 d100 rolls for event focus, event action, and event subject. The focuses are things like "Move towards a plot thread" or "Introduce a new character". The action and subject tables are lists of words. It's up to you how you string it together to generate a reasonable scenario.
I haven't got my campaign notes with me as I'm "travelling" myself, but at one system I got something like "Neutral event / Vengeance / Posessions". I decided this meant the two middle-passangers the crew had scrounged up on their Pop-3 stop were actually skip tracers with a lead that a stolen ship was holed up in grounddock at an outpost in the system. The skip tracers hired the crew to fly them over to the outpost.
True enough, the crew are no more "PCs" than the criminals running the outpost, but I identify more with the crew than I do with the other characters, so they are "the PCs" to all intents and purposes.
I find it meshes quite well with a free trader setup in Traveller - visiting a system is a "scene". If it isn't modified, I just play out the trade and passengers and roll for random space encounters. If it is modified, I use Mythic's GM emulator to generate a scenario. It helps to have a few basic plots going on in the background - mine are pretty standard Traveller fare (a budding trade war between two megacorps, rivalry between noble houses, and a foreign plot to disrupt the Imperium's grip on the sector). MGT's character back story generation helps with inspiration, too.
I'm not saying it's as good as playing in a group, but that isn't an option for me right now owing to various real-life distractions, so it's not too bad as a substitute (for now anyway).