Here's a thought- the advances in biotech and cybernetics are not an accident.
Basic concept- the Space Gods always assumed they would be able to do as they please with the humans and other humanoid races.
However, they slumbered too long through technological ascent, and found that PA spinals and neutron weapons will tear them apart, they are far more vulnerable to human weapons then either party ever dreamed. That's why all the 'dreaming' under the sea, best radiation protection.
So there is a Cthulhu "Cold War" going on, where either side can't quite finish off the other and each side is working to change that.
Scenario #1- The Space Gods are working overtime to try and figure out an 'in' to disable humanity's technology, through secret horror labs, experimenting on hapless adventurers that go beyond the frontier and get snared, more mundane science labs, and a constant drumbeat of plots to use followers of Cthulhu to undermine/overthrow human governments, militaries, and obtain secrets. The humans are working overtime to be able to close with the Space Gods in their hidey holes hence the advanced biotech, cybernetics, etc.
Scenario #2- As above but in addition the Space Gods would have been crushed out of existence except for the human factionalism. A multipolar humanity does not trust itself and gives the SGs the breathing and operating room to survive and use the factions against each other, or tempt them with advantages over the others.
Scenario #3- Either or both of the above, in addition the SGs have penetrated enough into humanity to actually control one or more megacorps, some of whom did so willingly as agents of Cthulhu, and are actively seeking to gain control of at least one navy.
Scenario #4- As any of the above, but SGs are themselves factionalized. More like each SG is it's own faction- they are used to taking over a planet or region of systems and then ordering their territory as they wish, acting as their own nation-states AND species (variability in their appearance, abilities, etc. is a direct outcome of 'evolutionary' action each SG took to survive and rule on varying planets and conditions). In a sense, a redux of the Vilani Imperium's reactions to Terrans, with activities measured in 1000s of years the SGs are not geared to handle quick technological change, or use their full power in concert to quash the Terrans before they get going.