By that, I mean "In part or in whole divorced from the OTU, effectively a new universe albeit using the familiar Traveller trappings."
If you have, what kind of changes do you make or what sets your thing apart from the OTU? Is it a variant or is it a reworking of it all?
When I was Refereeing I actually did take my players to very far out locations. Imagine you're part of a party of six or eight PCs double bunking on a type-S. Your nav software and other software is up to date, and your pilot is rated an expert. Well, the magic of being the Referee is that you are essentially "god" for the night, and what you say, goes. I say that because I would force a die roll for a misjump, although I wouldn't always tell the players. They'd roll, and whatever it was, I railroaded them this one time to get them to where I wanted to take them.
There's a shot at the end of Carl Sagan's original COSMOS TV series where he mentions a "Galaxy Rise". Suddenly that misjump (which I actually did) took both ship and players to some world way out in a "polar orbit" around the Milky Way galaxy.
The actual adventure dealt with some local raiders / mercenaries terrorizing the local planets. Normally that would be a huge challenge, only the opposition, though space faring, had inferior technology.
I also took my players to a Gamma World setting. I saw this Gamma World module;
To view the full piece of art, do a search for Larry Future Scape (
http://www.starfrontiers.us/files/u4436/e-Larry-Future-Snowscape-2013_06_12-12-44-10.jpg). Needless to say, I bought this, read it, was somewhat dissapointed in the content, but still ran the adventure making the behemoth you see on the cover as the ultimate combat objective. Again, it was a mobile fortress that was from a long dead civilization, and where the captain and crew were descendants of the original crew and various conquered villages, and they had enough know how to keep this thing going.
I also wanted to take one of my player groups to Tolkien's Middle Earth, but never did. I had planned an adventure essentially taking that same group to Miyazaki's "Castle in the Sky" or "Laputa", but never had a chance.
There were a couple of settings from fantasy comics that I touched on, as well as some paintings by Syd Mead. But in each of those adventures the Imperium was still there, but as per my other posts, hanging around in the background. Only my players had either gone to a world that was uncharted yet within the Imperium, or had been swept to some place exceptionally far away from the Imperium as to be way out of the OTU, but still carrying with them a Type-S with the Imperial sunburst, ACRs, or other equipment from the Imperium.
I still have lots of other settings that I would like to explore as both game environments for Traveller, or as visual media in the sci-fi genre apart from Traveller but with Traveller like conventions. Maybe something out of John Carter of Mars, or one of my favorite anime films; "Robot Carnival". It might be a hoot to push the envelope even further, and take that same group of players, and have them misjump to a parallel universe; and then plop them down in your favorite movie, novel or comic book setting.
So, the short answer; yes.