It's definitively a good topic. I use a non-canon setting (although there is still an Imperium) so for the major worlds around which I center the campaign I do trade on a world by world basis in view of the other worlds within J1-J3 as the primary direct trade partners.
I use a fair bit of detail to decide what a world needs and what it has for trade purposes. Volume of trade, trade stability and political stability dictates ship size. I use HG style for ship design, with some varaitions (e.g. lower crew size for civillian ships, dual use cargo/fuel bays), and have basically found bigger cargo ships are more economical IF you can afford the capital investment.
For example, on a trade route between a TL11+, Pop. B, world and a sparsely settled TL8-10, Pop. 7 forest "colony" world; 200,000 dton vessels are being used to transport biological products (including luxury items like wood, whole tree trunks, live animals, etc.). Smaller vessels of all sizes are being used as well.
Basically, the Pop. B world is in the process of wholescale harvesting of the forests (inlcuding everything in them) on a "sustainable" basis: complete harveting of continent 1 in 100 years, let rest for 100 years and harvest continent 2 for 100 years etc., continent 3 set as a preserve. These huge ships make economic sense in this setting as the Corp. that owns the ships also owns the rights to the land being harvested as well as the on colony world facilities, workers etc.
Of course, Corps. that could afford such ships can also afford political influence that might make the cost of operating such huge ships even more attractive due to tax breaks, price fixing, etc.
The ship size may seem astounding, but consider the volume of oil being shipped to the U.S. alone and the size of the ships, relative to the largest warships, being used to transport it, and the 200 kton may even seem a little small.