That's a great point. The metaphor Marc used was that of the Interstate highway system, connecting major population centers while bypassing all of the nothing-towns that used to thrive on the state highways. Route 66 is dotted with now-unvisited towns, since I-40 is a much more convenient way to get around.
Also, today, consider the term "flyover country" and how it's used as a negative context.
You can also see it in other ways: the decline of "brick and mortar" retail, how improved efficiency, lower labor, plus international sources affect the plains states and the decline of farms and small farming communities.
Heck, simply the reliability of modern vehicles, the improved create comforts, and higher highway speeds contribute.