As a GM who regularly has his campaigns devolve into big ship battles, I'd say I have good experience with this.
Talking mostly from a Classic Traveller screen, since each version modifies things a bit one way or the other.
First, there is no sense making a ship bigger than your spinal mount & protection level warrants; all extra mounts not specifically to support your ships main weapon just give you fewer spinal mounts per BCr spent, which means you end up losing.
HG, you need Agility 6, best computer to even stand a chance in the line, if you don't have that, go home
A Meson gun can be too big; since you really only need to shatter the fuel tanks or destroy some vital component with a crit. So 6-10 rolls on the internals table is enough to kill the biggest ship. So, again, you're better off with a 8x 1000 ton meson gun than an 8000 ton one. Since for the same Jump/maneuver/armor/meson screen you're talking constant percentages, it almost is a linear scale for main weapon size vs. ship size. Add in the bonus to hit bigger ships, and you have another reason to keep line ships as small as possible.
Prior to the effective meson screen (TL!4), your ships really cannot stand against a meson armed fleet; so fielding the most meson guns you can to disable the enemy as fast as possible is the paradigm. HG computer TL limits coupled with computer max ship size leave you having pretty lame ship[s early.
Some paradigm ships
Code:
Vilanesh Armored Cruiser CA-K113(1)4D3-A9(7)0002-80C07(6)-1 MCr22924.3714 19500 Tons TL:10
Cargo 17.8 Frozen Watch Fuel 2730 EP 780 Agility 1 Crew 167 Marines 20
3x 30 ton Ship's Boat Fuel Scoops and Purifiers.
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Code:
Thuvia Battle Cruiser CB-P1256E(+5fib)4-49(26,32)0004-667B6(24,30)-4 MCr85448.0008 74000 Tons
Cargo 8 Frozen Watch Fuel 19240 EP 4440 Agility 5 Crew 1050
Pulse Lasers 10x 90 ton Shuttle 21x 40 ton Fighter in 3 Squadrons Fuel Scoops and Purifiers.
Backup 5fib Computer
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Code:
Humicar Battleship BB-P(+b)13(0)68F(+6fib)3-C9(22,27)1(+1)1(+1)06-8(4,5)78K6(22,27)-1 MCr116336.946 70000 Tons TL:12
Cargo 62 Frozen Watch Fuel 5600 EP 5600 Agility 6 Crew 664 Marines 200
Low Passengers 432 6x 50 ton Interceptor Fuel Scoops and Purifiers.
Backup Bridge. 6fib Computer, Meson Screen 1, Nuclear Damper 1
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Code:
Defiant Strike Cruiser CS-J136(0)AG2-29(4)3300-700E7(3)-0 MCr8609.24 9000 Tons
Cargo 50.4 Frozen Watch Fuel 3600 EP 900 Agility 0 Crew 98
Pulse Lasers Fuel Scoops and Purifiers.
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Code:
Kali Light Cruiser CL-L136BH(+8fib)3-09(10,11)6(+6)6(+6)08-900G9(10)-1 26003.5776 MCr 24000 Tons TL:14
Cargo 30.2 Frozen Watch Fuel 9840 EP 2640 Agility 6 Crew 225 Marines 15
2x 50 ton Cutter Fuel Scoops and Purifiers.
Backup 8fib Computer, Meson Screen 6, Nuclear Damper 6
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Code:
DuPage Light Cruiser CL-K146CJ3-09(8)7709-760G7(9)-0 MCr16571.5022 19900 Tons TL:15
Cargo 124.2 Frozen Watch Fuel 10348 EP 2388 Agility 6 Crew 162 Marines 20
Fuel Scoops and Purifiers.
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Anyway, that's my 2 cents.
I recently had some fast cruisers fight some Particle beam destroyers of lower TL and the unarmored Meson tuned ships suffered, so possibly back up things like this with a screen of Small sized missile escorts, packing as high a factor missile as you can muster on a tiny super-armored hull (planetoid hull if you can).