Carbon dioxide (CO2) is naturally present in the atmosphere at levels of approximately 0.035%. Short-term exposure to CO2 at levels below 2% (20,000 parts per million or ppm) has not been reported to cause harmful effects. Higher concentrations can affect respiratory function and cause excitation followed by depression of the central nervous system. High concentrations of CO2 can displace oxygen in the air, resulting in lower oxygen concentrations for breathing. Therefore, effects of oxygen deficiency may be combined with effects of CO2 toxicity.
Volunteers exposed to 3.3% or 5.4% CO2 for 15 minutes experienced increased depth of breathing. At 7.5%, a feeling of an inability to breathe (dyspnea), increased pulse rate, headache, dizziness, sweating, restlessness, disorientation, and visual distortion developed. Twenty-minute exposures to 6.5 or 7.5% decreased mental performance. Irritability and discomfort were reported with exposure to 6.5% for approximately 70 minutes. Exposure to 6% for several minutes, or 30% for 20-30 seconds, has affected the heart, as evidenced by altered electrocardiograms.
As far as adaptation to such conditions, the 50 or so generations might not be enough.
(1000yrs and 20yrs between generations, for example )
Workers briefly exposed to very high concentrations showed damage to the retina, sensitivity to light (photophobia), abnormal eye movements, constriction of visual fields, and enlargement of blind spots. Exposure to up to 3.0% for over 15 hours, for six days, resulted in decreased night vision and colour sensitivity.
Exposure to 10% for 1.5 minutes has caused eye flickering, excitation and increased muscle activity and twitching. Concentrations greater than 10% have caused difficulty in breathing, impaired hearing, nausea, vomiting, a strangling sensation, sweating, stupor within several minutes and loss of consciousness within 15 minutes. Exposure to 30% has quickly resulted in unconsciousness and convulsions. Several deaths have been attributed to exposure to concentrations greater than 20%. Effects of CO2 can become more pronounced upon physical exertion, such as heavy work.