Combat-wise, they are the same, I believe.
Well, it depends. Potentially one or more of the A-units could be damaged, leaving the others functional, whereas a single D-unit could be taken entirely out of commission. Now in T5 space combat it would be based on how a compartment hit was interpreted and where the drives were located. In the Gazelle example, a 2A2 Drive (Port A2 & Starboard A2), clearly not all of them are located in the same compartment, and cannot all be hit at once. This allows for "crippling" the port M-Drive (or even only one of the two port M-Drives if they are sufficiently spaced dorsally/ventrally, compartment-wise), leaving the Starboard Drive(s) intact.