Considering we are still discovering new life on this planet, I would question how much they would know about thousands of other planets, many of them with little or only a precursory exam.
Valid question but, it is coming from a person (you & I) living in a low TL society.
There will be a finite number of combos that make life. And there will be a couple of things that will kill all you are concerned about. Such as breaking everything down to simple molecules via energy.
That was too easy.
